SCHEMBL2249446

SCHEMBL2249446

O=C(Nc1ccc(O)c(-c2nc3ccccc3s2)c1)c1cccc2ccccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 13/20 0.67
MEN1 O00255 6/20 0.67
KMT2A Q03164 6/20 0.67
KDM4E B2RXH2 1/20 0.67
RAB9A P51151 1/20 0.67
LMNA P02545 4/20 0.66
GAA P10253 1/20 0.66
SMN1; SMN2 Q16637 2/20 0.65
HPGD P15428 1/20 0.65
POLB P06746 2/20 0.63
CNR1 P21554 1/20 0.60
RXFP1 Q9HBX9 5/20 0.58
TP53 P04637 4/20 0.55
EGFR P00533 1/20 0.55
INSR P06213 1/20 0.55
IGF1R P08069 1/20 0.55
PDGFRB P09619 1/20 0.55
SRC P12931 1/20 0.55
CDK2 P24941 1/20 0.55
FLT4 P35916 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29401486 0.86 MAPT (0.69) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL28452457 0.86 MAPT (0.69) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12963179 0.86 MAPT (0.73) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12963181 0.86 MAPT (0.76) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL2246045 0.84 MAPT (0.66) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL2248103 0.83 MAPT (0.74) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL2246115 0.81 MAPT (1.00) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12963178 0.80 MAPT (0.66) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL2245625 0.80 MAPT (0.76) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12980262 0.80 MAPT (0.69) MAPTMEN1KMT2AKDM4ERAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-20110196075-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR SABIC INNOVATIVE PLASTICS IP B.V. 2011-08-11 US disclosed
US-20110196075-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR SABIC INNOVATIVE PLASTICS IP B.V. 2011-08-11 US disclosed
US-20110196075-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR SABIC INNOVATIVE PLASTICS IP B.V. 2011-08-11 US disclosed
WO-2008042497-A2 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS USEFUL AS AUTHENTICATION COMPOUNDS IN POLYMER ARTICLES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-04-10 WO disclosed
WO-2008042497-A2 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS USEFUL AS AUTHENTICATION COMPOUNDS IN POLYMER ARTICLES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-04-10 WO disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
WO-2008039587-A1 AUTHENTICATABLE POLYMER ARTICLES COMPRISING BENZOXAZOLE AND BENZOTHIAZOLE AUTHENTICATION COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-04-03 WO disclosed
WO-2008039587-A1 AUTHENTICATABLE POLYMER ARTICLES COMPRISING BENZOXAZOLE AND BENZOTHIAZOLE AUTHENTICATION COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-04-03 WO disclosed
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080081913-A1 BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR CYP4F11, NPY1R, CYP51A1 MAPT 2630/4885MEN1 1197/4885KMT2A 3476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.