Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | BLK | P51451 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2253478 | 0.87 | ALDH1A1 (0.42) | JAK2KDM4EALDH1A1SRCPIM1 | |
| SCHEMBL2253785 | 0.85 | KDM4E (0.40) | JAK2KDM4EALDH1A1SRCPIM1 | |
| SCHEMBL2249732 | 0.83 | KDR (0.40) | JAK2KDM4EALDH1A1SRCKDR | |
| SCHEMBL2255214 | 0.81 | PIK3CG (0.37) | JAK2KDM4EALDH1A1SRCPIM1 | |
| SCHEMBL2251336 | 0.81 | JAK2 (0.43) | JAK2KDM4EALDH1A1 | |
| SCHEMBL18615218 | 0.81 | JAK2 (0.67) | MPLJAK2F2RL3 | |
| SCHEMBL2254007 | 0.80 | SRC (0.41) | JAK2KDM4EALDH1A1SRCKDR | |
| SCHEMBL2249571 | 0.78 | JAK2 (0.52) | MPLJAK2KDM4EALDH1A1PIK3CD | |
| SCHEMBL2273504 | 0.75 | JAK2 (0.46) | JAK2KDM4EALDH1A1CSF1R | |
| SCHEMBL2256469 | 0.75 | JAK2 (0.42) | JAK2KDM4EALDH1A1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531503-A1 | GAMMA SECRETASE MODULATERS | F. Hoffmann-La Roche AG (CH) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011092272-A1 | GAMMA SECRETASE MODULATERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-04 | — | — | WO | disclosed |
| US-20110190269-A1 | GAMMA SECRETASE MODULATORS | HOFFMANN-LA ROCHE, INC. | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190269-A1 | GAMMA SECRETASE MODULATORS | BACE1, APH1A, APH1B | MPL 3084/4885JAK2 4637/4885F2RL3 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.