Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.52 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15163323 | 0.90 | EGFR (0.69) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL2249784 | 0.89 | EGFR (0.75) | EGFRERBB2LCKERBB4 | |
| SCHEMBL2249394 | 0.88 | EGFR (0.73) | EGFRERBB2LCKERBB4 | |
| SCHEMBL2250506 | 0.87 | EGFR (0.77) | EGFRERBB2LCKERBB4 | |
| SCHEMBL2251513 | 0.87 | EGFR (0.69) | EGFRERBB2LCKERBB4ERBB3 | |
| SCHEMBL2248785 | 0.87 | EGFR (0.72) | EGFRERBB2LCKERBB4 | |
| SCHEMBL2252459 | 0.86 | EGFR (0.84) | EGFRERBB2LCK | |
| SCHEMBL2255370 | 0.85 | EGFR (0.74) | EGFRERBB2LCKERBB4 | |
| SCHEMBL2255502 | 0.85 | EGFR (0.80) | EGFRERBB2 | |
| SCHEMBL15163063 | 0.85 | EGFR (0.73) | EGFRERBB2LCKERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003658-B2 | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-23 | — | — | US | claimed |
| US-8003658-B2 | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-23 | — | — | US | disclosed |