Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.77 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.77 |
| ▸ | EML4 | Q9HC35 | 5/20 | 0.77 |
| ▸ | JAK3 | P52333 | 7/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | JAK1 | P23458 | 2/20 | 0.57 |
| ▸ | TYK2 | P29597 | 2/20 | 0.57 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.57 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | FER | P16591 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | BLK | P51451 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22520143 | 0.92 | EGFR (0.65) | EGFRALKEML4JAK3JAK2 | |
| SCHEMBL22520220 | 0.91 | EGFR (0.77) | EGFRALKEML4JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL29783050 | 0.91 | EGFR (0.64) | EGFRALKEML4JAK3JAK2 | |
| SCHEMBL22520100 | 0.89 | EGFR (0.62) | EGFRALKEML4JAK3JAK2 | |
| SCHEMBL22520157 | 0.88 | JAK3 (0.61) | EGFRALKEML4JAK3JAK2 | |
| SCHEMBL22497656 | 0.87 | EGFR (1.00) | EGFRALKEML4PTK2ERBB2 | |
| SCHEMBL22497633 | 0.86 | EGFR (0.77) | EGFRALKEML4 | |
| SCHEMBL28059271 | 0.86 | EGFR (0.63) | EGFRJAK3JAK2JAK1TYK2 | |
| SCHEMBL17766079 | 0.86 | EGFR (0.79) | EGFRALKEML4JAK3JAK2 | |
| SCHEMBL22520155 | 0.85 | EGFR (0.59) | EGFRALKEML4PTK2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020200191-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THERE OF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020200191-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THERE OF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-10-08 | — | — | WO | disclosed |