Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | BTK | Q06187 | 5/20 | 0.63 |
| ▸ | JAK3 | P52333 | 7/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.62 |
| ▸ | JAK1 | P23458 | 2/20 | 0.62 |
| ▸ | TYK2 | P29597 | 2/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.62 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26876001 | 0.88 | JAK3 (0.67) | EGFRJAK3JAK2JAK1TYK2 | |
| SCHEMBL28059336 | 0.88 | EGFR (0.63) | EGFRBTKJAK3JAK2 | |
| SCHEMBL28059335 | 0.88 | EGFR (0.63) | EGFRBTKJAK3JAK2 | |
| SCHEMBL22520157 | 0.87 | JAK3 (0.61) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL24621334 | 0.87 | JAK3 (0.66) | EGFRJAK3JAK2JAK1TYK2 | |
| SCHEMBL26875251 | 0.86 | JAK3 (0.65) | EGFRJAK3JAK2JAK1TYK2 | |
| SCHEMBL22497648 | 0.86 | EGFR (0.77) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL18000712 | 0.86 | JAK3 (0.60) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL17766079 | 0.85 | EGFR (0.79) | EGFRBTKJAK3JAK2JAK1 | |
| SCHEMBL28059266 | 0.83 | EGFR (0.77) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |