Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | IAPP | P10997 | 3/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22498572 | 0.86 | PTGER1 (0.49) | PTGER1PTGER4PTGER3PTGER2FFAR1 | |
| SCHEMBL2962744 | 0.83 | TAAR1 (0.50) | PPARGPPARATAAR1FFAR1FFAR4 | |
| SCHEMBL11349111 | 0.81 | TAAR1 (0.55) | TAAR1CTSGCMA1TNKSTNKS2 | |
| SCHEMBL18371375 | 0.81 | IAPP (0.38) | TAAR1IAPPFFAR1FFAR4GPR52 | |
| SCHEMBL17605475 | 0.81 | IAPP (0.34) | TAAR1IAPPPTGER1PTGER4PTGER3 | |
| SCHEMBL12719449 | 0.77 | GPR17 (0.41) | FFAR1FFAR4THRATHRBALDH1A1 | |
| SCHEMBL25392754 | 0.75 | TAAR1 (0.41) | PPARGPPARAMRGPRX4TAAR1GABRA1 | |
| SCHEMBL5902835 | 0.74 | AKR1B1 (0.48) | PPARGPPARAMRGPRX4 | |
| SCHEMBL3813861 | 0.73 | TAAR1 (0.52) | TAAR1 | |
| SCHEMBL31152963 | 0.72 | GABRA1 (0.56) | PPARGPPARAMRGPRX4TAAR1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113544129-B | Tricyclic compound preparation method and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-113544129-A | Tricyclic compound preparation method and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020200284-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |