SCHEMBL22499802

SCHEMBL22499802

CC(O)(COc1ccc(N2CCC(Oc3ccc(OC(F)(F)F)cc3)CC2)cc1)Cn1cc([N+](=O)[O-])nc1Br

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.57
SLC6A2 P23975 1/20 0.57
SLC6A4 P31645 1/20 0.57
KCNH2 Q12809 6/20 0.44
ACACB O00763 4/20 0.41
CHRM1 P11229 1/20 0.37
MCHR1 Q99705 6/20 0.36
CHRM4 P08173 1/20 0.36
SCN5A Q14524 1/20 0.36
SCN9A Q15858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19809307 0.91 PTGS1 (0.57) PTGS1SLC6A2SLC6A4KCNH2ACACB
SCHEMBL2951490 0.91 PTGS1 (0.57) PTGS1SLC6A2SLC6A4KCNH2ACACB
SCHEMBL5543740 0.83 PTGS1 (0.45) PTGS1SLC6A2SLC6A4KCNH2CHRM1
SCHEMBL5543733 0.83 PTGS1 (0.45) PTGS1SLC6A2SLC6A4KCNH2CHRM1
SCHEMBL19929307 0.82 PTGS1 (0.58) PTGS1SLC6A2SLC6A4KCNH2ACACB
SCHEMBL12902233 0.79 KCNH2 (0.40) PTGS1SLC6A2SLC6A4KCNH2CHRM1
SCHEMBL22527429 0.77 KCNH2 (0.54) PTGS1SLC6A2SLC6A4KCNH2ACACB
SCHEMBL2314441 0.77 KCNH2 (0.54) PTGS1SLC6A2SLC6A4KCNH2ACACB
SCHEMBL2311795 0.77 KCNH2 (0.54) PTGS1SLC6A2SLC6A4KCNH2ACACB
SCHEMBL1228757 0.77 CHRM1 (0.44) PTGS1SLC6A2SLC6A4KCNH2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113874341-B Process for preparing derivatives of 1, 1-dialkylethane-1, 2-diols useful as intermediates 科学与工业研究委员会 2024-05-31 CN disclosed
CN-113874341-A Process for preparing derivatives of 1, 1-dialkylethane-1, 2-diols as useful intermediates 科学与工业研究委员会 2021-12-31 CN disclosed
WO-2020202205-A1 PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1,1-DIALKYLETHANE-1,2-DIOLS AS USEFUL INTERMEDIATES COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2020-10-08 WO disclosed