Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16060264 | 0.89 | DDB1 (0.44) | NR1H2DDB1CRBNHPGDSNAMPT | |
| SCHEMBL30793215 | 0.88 | HPGDS (0.42) | NR1H2DDB1CRBNHPGDSNAMPT | |
| SCHEMBL20792882 | 0.78 | HPGDS (0.48) | NR1H2DDB1CRBNHPGDSMAPT | |
| SCHEMBL16217193 | 0.78 | HPGDS (0.52) | NR1H2DDB1CRBNHPGDSNAMPT | |
| SCHEMBL16210651 | 0.78 | ESR2 (0.48) | NR1H2DDB1CRBNHPGDSMAPT | |
| SCHEMBL20364274 | 0.78 | NR1H2 (0.46) | NR1H2DDB1CRBNHPGDSNAMPT | |
| SCHEMBL23852254 | 0.76 | HPGDS (0.50) | NR1H2DDB1CRBNHPGDSNAMPT | |
| SCHEMBL31739445 | 0.76 | HPGDS (0.46) | NR1H2DDB1CRBNHPGDSNAMPT | |
| SCHEMBL23852997 | 0.76 | HPGDS (0.48) | NR1H2DDB1CRBNHPGDSNAMPT | |
| SCHEMBL23794840 | 0.76 | HPGDS (0.48) | NR1H2DDB1CRBNHPGDSNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225479-B2 | Bicyclic inhibitors of histone deacetylase | ALKERMES, INC. (US) | 2022-01-18 | — | — | US | disclosed |
| US-20210122748-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2021-04-29 | — | — | US | disclosed |
| US-10793567-B2 | Bicyclic inhibitors of histone deacetylase | RODIN THERAPEUTICS, INC. (US) | 2020-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210122748-A1 | BICYCLIC INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC3 | NR1H2 175/4885DDB1 1903/4885CRBN 1056/4885 |
| US-10793567-B2 | Bicyclic inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC11 | NR1H2 227/4885DDB1 2017/4885CRBN 1536/4885 |
| US-11225479-B2 | Bicyclic inhibitors of histone deacetylase | HDAC2, HDAC1, HDAC3 | NR1H2 175/4885DDB1 1903/4885CRBN 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.