Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25340410 | 0.82 | HTT (0.59) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL29907964 | 0.82 | HTT (0.59) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL22576482 | 0.79 | ESR1 (0.52) | ALDH1A1PKMKDM4EPOLBESR1 | |
| SCHEMBL22467593 | 0.79 | HTT (0.43) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL29645214 | 0.79 | HTT (0.43) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL21107996 | 0.78 | POLB (0.41) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL29645215 | 0.78 | POLB (0.41) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL24287859 | 0.76 | ALDH1A1 (0.54) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL24287938 | 0.71 | ALDH1A1 (0.59) | ALDH1A1PKMKDM4EPOLBHTT | |
| SCHEMBL30494008 | 0.71 | ALDH1A1 (0.59) | ALDH1A1PKMKDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319309-B2 | Cyclohexyl acid isoxazole azines as LPA antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-05-03 | — | — | US | disclosed |
| US-20200317656-A1 | CYCLOHEXYL ACID ISOXAZOLE AZINES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11319309-B2 | Cyclohexyl acid isoxazole azines as LPA antagonists | LPAR1, LPAR2, LPAR5 | ALDH1A1 1903/4885PKM 2794/4885KDM4E 3787/4885 |
| US-20200317656-A1 | CYCLOHEXYL ACID ISOXAZOLE AZINES AS LPA ANTAGONISTS | LPAR1, LPAR2, LPAR5 | ALDH1A1 1903/4885PKM 2794/4885KDM4E 3787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.