Sugi Predict

Sugi Predict / Compounds / SCHEMBL225044

SCHEMBL225044

SCHEMBL225044

COC(=O)C1(C(=O)OC)CC1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.46
▸ LMNA P02545 1/20 0.40
▸ CYP4F2 P78329 1/20 0.38
▸ CYP4A11 Q02928 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.37
▸ MAPT P10636 1/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.32
▸ KEAP1 Q14145 1/20 0.32
▸ NFE2L2 Q16236 1/20 0.32
▸ HCAR2 Q8TDS4 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ CYP2C9 P11712 1/20 0.31
▸ PKM P14618 1/20 0.31
▸ CYP2C19 P33261 1/20 0.31
▸ FFAR3 O14843 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12462298 1.00 NPSR1 (0.46) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL14128893 0.89 NPSR1 (0.40) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL4862476 0.89 NPSR1 (0.40) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL230256 0.88 NPSR1 (0.48) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL759802 0.88 NPSR1 (0.54) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL594374 0.86 NPSR1 (0.52) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL71320 0.86 NPSR1 (0.41) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL4870814 0.86 NPSR1 (0.52) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL3606720 0.86 NPSR1 (0.41) NPSR1LMNACYP4F2CYP4A11ALDH1A1
SCHEMBL9806699 0.86 NPSR1 (0.52) NPSR1LMNACYP4F2CYP4A11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 218 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108383998-B A kind of high intensity humidity response polyhydroxyamide and preparation method thereof 安徽农业大学 2019-10-08 — — CN claimed
CN-109438416-A A kind of method of synthesizing thiofuran class inhibitor TPCA-1 河南师范大学 2019-03-08 — — CN claimed
JP-10067711-A — — None — — JP disclosed
US-12637433-B2 Histone deacetylase inhibitors THE UNIVERSITY OF QUEENSLAND (AU) 2026-05-26 — — US disclosed
US-12637680-B2 Recombinant host cells for the production of malonate LYGOS, INC. (US) 2026-05-26 — — US disclosed
WO-2025245089-A1 PROCESSES FOR PREPARING TETRALIN COMPOUNDS ARCUS BIOSCIENCES, INC. (US) 2025-11-27 — — WO disclosed
CN-119709450-A Recombinant host cells for malonate production 利戈斯股份有限公司 2025-03-28 — — CN disclosed
US-20250092027-A1 ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY ASTEX THERAPEUTICS LIMITED (GB) 2025-03-20 — — US disclosed
CN-115572252-B Isoindolinone inhibitors of MDM2-P53 interaction with anticancer activity 阿斯泰克斯治疗有限公司 2025-02-25 — — CN disclosed
CN-114616330-B Recombinant host cells for malonate production 利戈斯股份有限公司 2025-01-03 — — CN disclosed
CN-113135896-B Methylpyrazole derivatives as RET inhibitors 正大天晴药业集团股份有限公司 2024-12-06 — — CN disclosed
US-5463111-A Process for preparing dialkyl 2-haloethyl malonates HULS AKTIENGESELLSCHAFT (DE) 1995-10-31 — — US disclosed
US-5412120-A Catalytic decarboxylation of corresponding geminal dicarboxylic acid BASF AKTIENGESELLSCHAFT (DE) 1995-05-02 — — US disclosed
US-5334747-A Reacting substituted malonic acid dialkyl ester with aniline in presence of stoichiometric amount of alkali alcoholate, neutralizing product with acid, saponifying with water HULS AKTIENGESELLSCHAFT (DE) 1994-08-02 — — US disclosed
US-5278316-A Indoles WARNER-LAMBERT COMPANY (US) 1994-01-11 — — US disclosed
EP-0479910-A1 N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED Trp-Phe- AND PHENETHYLAMINE DERIVATIVES WARNER-LAMBERT COMPANY (US) 1992-04-15 — — EP disclosed
WO-1991000274-A1 N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED TRP-PHE- AND PHENETHYLAMINE DERIVATIVES WARNER-LAMBERT COMPANY (US) 1991-01-10 — — WO disclosed
EP-0405537-A1 N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives WARNER-LAMBERT COMPANY (US) 1991-01-02 — — EP disclosed
US-4069277-A ZINC DIHYDROCARBYL DITHIOPHOSPHINATE PHILLIPS FIBERS CORPORATION (US) 1978-01-17 — — US disclosed
US-4059653-A ZINC ALKYL SULFINATE PHILLIPS PETROLEUM COMPANY (US) 1977-11-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250092027-A1 ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY TP53, MDM2, TP53BP1 NPSR1 4167/4885LMNA 2027/4885CYP4F2 2903/4885
US-12637433-B2 Histone deacetylase inhibitors HDAC1, HDAC11, HDAC3 NPSR1 4044/4885LMNA 1447/4885CYP4F2 3861/4885
US-12637680-B2 Recombinant host cells for the production of malonate DCXR, ETV1, LYPLA2 NPSR1 4501/4885LMNA 4287/4885CYP4F2 222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.