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Sugi Predict / Targets / LYPLA2

LYPLA2

Acyl-protein thioesterase 2 · O95372 · LYPLA2 on Sugi Atlas →

2,854 patent compounds predicted against LYPLA2, 2,218 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL12370961 SCHEMBL12370961 0.59 6/20
SCHEMBL12370966 SCHEMBL12370966 0.52 6/20
SCHEMBL3402991 SCHEMBL3402991 0.51 6/20
SCHEMBL10083462 SCHEMBL10083462 0.55 5/20
SCHEMBL10555179 SCHEMBL10555179 0.50 5/20
SCHEMBL12395555 SCHEMBL12395555 0.43 5/20
SCHEMBL4432746 SCHEMBL4432746 0.64 4/20
SCHEMBL7623021 SCHEMBL7623021 0.64 4/20
SCHEMBL712929 SCHEMBL712929 0.60 4/20
SCHEMBL714006 SCHEMBL714006 0.60 4/20
SCHEMBL715056 SCHEMBL715056 0.60 4/20
SCHEMBL10073515 SCHEMBL10073515 0.60 4/20
SCHEMBL13310145 SCHEMBL13310145 0.60 4/20
SCHEMBL714172 SCHEMBL714172 0.57 4/20
SCHEMBL714173 SCHEMBL714173 0.57 4/20
SCHEMBL2917942 SCHEMBL2917942 0.57 4/20
SCHEMBL2918348 SCHEMBL2918348 0.57 4/20
SCHEMBL3447306 SCHEMBL3447306 0.57 4/20
SCHEMBL4047137 SCHEMBL4047137 0.56 4/20
SCHEMBL5847255 SCHEMBL5847255 0.55 4/20

Clinical trials — most relevant to LYPLA2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis PHASE4COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency PHASE3COMPLETED
Ambroxol as a Treatment for Parkinson's Disease Dementia PHASE2UNKNOWN
Cholic Acid for Hepatic Steatosis in Lipodystrophy PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Insulin Regulation of Lipolysis and Lipolysis Proteins EARLY_PHASE1RECRUITING
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects) nanUNKNOWN
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
The Classification and Cause of Leukodystrophies of Unknown Cause nanCOMPLETED
Genes Involved in Lipid Disorders nanCOMPLETED
Epidemiology of Atherosclerosis nanCOMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects nanUNKNOWN
for Adipose Tissue DIabetes VAriants (fATDIVA) nanCOMPLETED
Genetic Mapping of Atherogenic Lipoprotein Phenotypes nanCOMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children nanWITHDRAWN
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase. nanUNKNOWN
Biomarker for Wolman Disease (BioWolman) nanWITHDRAWN
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL) nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies nanUNKNOWN
Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease nanENROLLING_BY_INVITATION
Natural History of the Leukodystrophies nanCOMPLETED
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype nanCOMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN) nanCOMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study nanCOMPLETED
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With Classic Polycystic Ovary Syndrome (PCOS) nanNOT_YET_RECRUITING
Psychological and Biological Markers of Refractory Migraine nanUNKNOWN
Lipodystrophy Connect Patient Registry nanCOMPLETED
Pharmacogenetics of Hypertriglyceridemia in Hispanics nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a LYPLA2 binder may also engage these)

ProteinNameSimilarity
Q9WTL7 — 1.000 Q9WTL7 →
Q9QYL8 — 1.000 Q9QYL8 →
Q6DD70 — 0.935 Q6DD70 →
Q6GL10 — 0.934 Q6GL10 →
Q99JW1 — 0.934 Q99JW1 →
Q7ZVZ7 — 0.929 Q7ZVZ7 →
Q5XIJ5 — 0.928 Q5XIJ5 →
Q2HJ19 — 0.924 Q2HJ19 →
Q96GS6 — 0.923 Q96GS6 →
Q5ZJ01 — 0.922 Q5ZJ01 →
Q2YDM2 — 0.921 Q2YDM2 →
Q9CWS4 — 0.920 Q9CWS4 →
Q5ZJX1 — 0.919 Q5ZJX1 →
F6V515 — 0.919 F6V515 →
Q6DCC5 — 0.919 Q6DCC5 →
Q6PCB6 — 0.919 Q6PCB6 →
Q9D2R0 — 0.918 Q9D2R0 →
Q8VCV1 — 0.918 Q8VCV1 →
Q3MHR0 — 0.918 Q3MHR0 →
Q5XJ36 — 0.917 Q5XJ36 →
B5DFK7 — 0.916 B5DFK7 →
Q5ZJL4 — 0.916 Q5ZJL4 →
Q5TA45 — 0.915 Q5TA45 →
Q503E1 — 0.915 Q503E1 →
Q3MHC2 — 0.915 Q3MHC2 →
P38024 — 0.915 P38024 →
Q0II59 — 0.915 Q0II59 →
A5PKD9 — 0.915 A5PKD9 →
Q99LX0 — 0.915 Q99LX0 →
Q9CZX0 — 0.914 Q9CZX0 →