Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250813 | 1.00 | KCNH2 (0.49) | KCNH2SLC2A1CDK4CDK2GSK3B | |
| SCHEMBL2248805 | 0.85 | KCNH2 (0.55) | KCNH2 | |
| SCHEMBL3251533 | 0.85 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL1147947 | 0.84 | KCNH2 (0.52) | KCNH2 | |
| SCHEMBL1147476 | 0.84 | KCNH2 (0.52) | KCNH2 | |
| SCHEMBL3687649 | 0.80 | KCNH2 (0.74) | KCNH2 | |
| SCHEMBL3687651 | 0.80 | KCNH2 (0.74) | KCNH2 | |
| SCHEMBL3687657 | 0.80 | KCNH2 (0.74) | KCNH2 | |
| SCHEMBL2250560 | 0.80 | KCNH2 (0.43) | KCNH2SLC2A1 | |
| SCHEMBL4137510 | 0.80 | KCNH2 (0.43) | KCNH2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999115-B2 | Spiro antibiotic derivatives | ACTELION PHARMACEUTICAL LTD. (SE) | 2011-08-16 | — | — | US | disclosed |