Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 14/20 | 0.73 |
| ▸ | STK17B | O94768 | 7/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21364892 | 0.87 | STK17A (0.66) | STK17ASTK17BHRH3CCNKCDK13 | |
| SCHEMBL22508341 | 0.87 | STK17A (0.76) | STK17ASTK17BHRH3CCNKCDK13 | |
| SCHEMBL20154728 | 0.84 | STK17A (1.00) | STK17ASTK17BHRH3CCNKCDK13 | |
| SCHEMBL22490561 | 0.84 | STK17A (0.76) | STK17ASTK17BHRH3CCNKCDK13 | |
| SCHEMBL22508340 | 0.84 | STK17A (0.75) | STK17ASTK17BHRH3CCNKCDK13 | |
| SCHEMBL21365160 | 0.81 | STK17A (0.67) | STK17ASTK17BHRH3CCNKCDK13 | |
| SCHEMBL21364894 | 0.79 | STK17A (0.64) | STK17ACCNKCDK13CDK12SYK | |
| SCHEMBL19476564 | 0.78 | TLR8 (0.63) | STK17AHRH3CCNKCDK13CDK12 | |
| SCHEMBL19477222 | 0.78 | TLR8 (0.63) | STK17AHRH3CCNKCDK13CDK12 | |
| SCHEMBL20154734 | 0.77 | STK17A (1.00) | STK17ASTK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539951-B1 | NOVEL PYRIMIDINE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER AND INFLAMMATORY DISEASES | KOREA RES INST CHEMICAL TECH (KR) | 2020-10-07 | — | — | EP | disclosed |