Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 5/20 | 0.49 |
| ▸ | ORAI1 | Q96D31 | 5/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | IL2 | P60568 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155561 | 0.89 | NPC1 (0.50) | STIM1ORAI1ABL1GRM5IL2 | |
| SCHEMBL12241399 | 0.87 | STIM1 (0.49) | STIM1ORAI1ABL1GRM5IL2 | |
| SCHEMBL12155541 | 0.84 | STIM1 (0.49) | STIM1ORAI1ABL1GRM5IL2 | |
| SCHEMBL12155539 | 0.83 | STIM1 (0.52) | STIM1ORAI1IL2F10KDM4E | |
| SCHEMBL12155573 | 0.83 | STIM1 (0.65) | STIM1ORAI1ABL1KDM4ENPC1 | |
| SCHEMBL12156191 | 0.81 | STIM1 (0.57) | STIM1ORAI1ABL1IL2KDM4E | |
| SCHEMBL12156189 | 0.81 | IL2 (0.54) | STIM1ORAI1ABL1IL2 | |
| SCHEMBL12155543 | 0.80 | STIM1 (0.56) | STIM1ORAI1ABL1KDM4ENPC1 | |
| SCHEMBL12155564 | 0.77 | RAB9A (0.48) | ABL1F10KDM4ENPC1ALDH1A1 | |
| SCHEMBL12156018 | 0.77 | STIM1 (0.53) | STIM1ORAI1ABL1GRM5IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200317617-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | AVENUE CAPITAL MANAGEMENT II, L.P. | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317617-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | STIM1 17/4885ORAI1 1/4885ABL1 4066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.