Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254158 | 0.93 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL24254253 | 0.91 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL22509702 | 0.91 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL22521415 | 0.84 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL23429766 | 0.79 | HRH2 (0.34) | PRMT5WDR77HRH2HTR5A | |
| SCHEMBL23430009 | 0.79 | HTR2B (0.38) | PRMT5WDR77HRH2HTR5A | |
| SCHEMBL22521414 | 0.79 | HTR2B (0.38) | PRMT5WDR77HRH2HTR5A | |
| SCHEMBL22521487 | 0.79 | HTR2B (0.38) | PRMT5WDR77HRH2HTR5A | |
| SCHEMBL29566386 | 0.79 | HTR2B (0.38) | PRMT5WDR77HRH2HTR5A | |
| SCHEMBL23405222 | 0.78 | PRMT5 (0.53) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020205867-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |