Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 20/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 19/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254253 | 1.00 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL22509700 | 0.91 | PRMT5 (0.47) | PRMT5WDR77 | |
| SCHEMBL23405222 | 0.87 | PRMT5 (0.53) | PRMT5WDR77 | |
| SCHEMBL22521507 | 0.84 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL22521484 | 0.84 | PRMT5 (0.58) | PRMT5WDR77 | |
| SCHEMBL22521493 | 0.84 | PRMT5 (0.55) | PRMT5WDR77 | |
| SCHEMBL24254158 | 0.84 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL22509882 | 0.82 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL22521415 | 0.76 | PRMT5 (0.46) | PRMT5WDR77 | |
| SCHEMBL23429828 | 0.74 | PRMT5 (0.58) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220048922-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. | 2022-02-17 | — | — | US | disclosed |
| WO-2020205867-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220048922-A1 | COMPOUNDS TARGETING PRMT5 | PRMT5, PRMT1, PRMT6 | PRMT5 1/4885WDR77 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.