Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 16/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 16/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254253 | 0.82 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL22509702 | 0.82 | PRMT5 (0.56) | PRMT5WDR77 | |
| SCHEMBL22509870 | 0.79 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL29706948 | 0.79 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL22509657 | 0.79 | PRMT5 (0.51) | PRMT5WDR77 | |
| SCHEMBL24092008 | 0.79 | PRMT5 (0.52) | PRMT5WDR77 | |
| SCHEMBL22521454 | 0.79 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL21061719 | 0.79 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL23430012 | 0.79 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 | |
| SCHEMBL29522691 | 0.79 | PRMT5 (0.42) | PRMT5WDR77ADKRAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020205867-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |