Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | JAK1 | P23458 | 1/20 | 0.63 |
| ▸ | TYK2 | P29597 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 12/20 | 0.63 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29253665 | 0.92 | JAK1 (0.57) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL29253766 | 0.92 | JAK3 (0.56) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL22520094 | 0.89 | EGFR (0.65) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL22497638 | 0.89 | EGFR (0.80) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL29253697 | 0.89 | ALK (0.68) | JAK2EGFRSRCFGFR1ALK | |
| SCHEMBL29253647 | 0.87 | JAK2 (0.54) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL19027409 | 0.87 | ALK (0.67) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL21558123 | 0.86 | EGFR (0.68) | JAK3EGFRALK | |
| SCHEMBL24621350 | 0.84 | JAK3 (0.66) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL22520128 | 0.83 | MAP3K7 (0.60) | EGFRMAP3K7MAP2K1SRCMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677680-B | EGFR inhibitor, composition and application thereof | 贝达药业股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| WO-2020200191-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THERE OF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-10-08 | — | — | WO | disclosed |