Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | SRC | P12931 | 6/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22520165 | 0.92 | JAK3 (0.63) | JAK1JAK2TYK2JAK3EGFR | |
| SCHEMBL29253766 | 0.92 | JAK3 (0.56) | JAK1JAK2TYK2JAK3EGFR | |
| SCHEMBL22520152 | 0.89 | EGFR (0.57) | JAK1EGFRBRD4FGFR3KDR | |
| SCHEMBL22497608 | 0.89 | EGFR (0.69) | JAK1JAK2TYK2JAK3EGFR | |
| SCHEMBL22520226 | 0.88 | EGFR (0.58) | EGFR | |
| SCHEMBL29253647 | 0.88 | JAK2 (0.54) | JAK1JAK2TYK2JAK3EGFR | |
| SCHEMBL19027408 | 0.87 | ALK (0.58) | JAK1JAK2TYK2JAK3EGFR | |
| SCHEMBL22520206 | 0.86 | EGFR (0.57) | JAK1EGFRBRD4FGFR3KDR | |
| SCHEMBL22520094 | 0.81 | EGFR (0.65) | JAK1JAK2TYK2JAK3EGFR | |
| SCHEMBL22520099 | 0.81 | EGFR (0.67) | JAK1JAK2TYK2JAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677680-B | EGFR inhibitor, composition and application thereof | 贝达药业股份有限公司 | 2024-05-10 | — | — | CN | disclosed |