⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12590300 | 0.68 | TAAR1 (0.45) | — | |
| SCHEMBL7939302 | 0.68 | TDP1 (0.33) | — | |
| SCHEMBL22911357 | 0.68 | PDE9A (0.30) | — | |
| SCHEMBL24524642 | 0.67 | ADORA3 (0.30) | — | |
| SCHEMBL21843828 | 0.65 | HRH4 (0.42) | — | |
| SCHEMBL20150446 | 0.65 | — | — | |
| SCHEMBL12590301 | 0.64 | HRH3 (0.53) | — | |
| SCHEMBL21325359 | 0.63 | KDM1A (0.33) | — | |
| SCHEMBL13681680 | 0.63 | — | — | |
| SCHEMBL20150242 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194932-A1 | IMPROVED INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | STEMSYNERGY THERAPEUTICS, INC. | 2022-06-23 | — | — | US | disclosed |
| WO-2020209933-A1 | IMPROVED INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2020-10-15 | — | — | WO | disclosed |