Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 8/20 | 0.42 |
| ▸ | JAK3 | P52333 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 7/20 | 0.42 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22544820 | 0.89 | EIF2AK4 (0.45) | EIF2AK4IKBKETBK1JAK1JAK3 | |
| SCHEMBL29754208 | 0.89 | EIF2AK4 (0.45) | EIF2AK4IKBKETBK1JAK1JAK3 | |
| SCHEMBL22544570 | 0.87 | LRRK2 (0.45) | EIF2AK4IKBKETBK1JAK1JAK3 | |
| SCHEMBL29754209 | 0.87 | LRRK2 (0.45) | EIF2AK4IKBKETBK1JAK1JAK3 | |
| SCHEMBL22544463 | 0.84 | JAK2 (0.43) | EIF2AK4IKBKETBK1JAK1JAK3 | |
| SCHEMBL29754214 | 0.81 | TBK1 (0.43) | IKBKETBK1JAK1JAK3JAK2 | |
| SCHEMBL22529468 | 0.81 | TBK1 (0.43) | IKBKETBK1JAK1JAK3JAK2 | |
| SCHEMBL27275032 | 0.81 | TBK1 (0.44) | IKBKETBK1JAK1JAK3JAK2 | |
| SCHEMBL29754205 | 0.80 | CDK4 (0.43) | IKBKETBK1JAK1JAK3JAK2 | |
| SCHEMBL22544557 | 0.80 | CDK4 (0.43) | IKBKETBK1JAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020206588-A1 | BENZETHERS AND ANILINES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO., LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |