Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29754170 | 1.00 | TBK1 (0.43) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL29754285 | 0.95 | LRRK2 (0.45) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL22544665 | 0.95 | LRRK2 (0.45) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL22544535 | 0.93 | MYLK4 (0.46) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL29754181 | 0.93 | MYLK4 (0.46) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL22529468 | 0.91 | TBK1 (0.43) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL29754214 | 0.91 | TBK1 (0.43) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL22544813 | 0.88 | MYLK4 (0.50) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL22544570 | 0.86 | LRRK2 (0.45) | TBK1IKBKELRRK2JAK2JAK3 | |
| SCHEMBL22544655 | 0.86 | IRAK4 (0.47) | TBK1IKBKEJAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024503-B2 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| US-12024503-B2 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2024-07-02 | — | — | US | disclosed |
| CN-113993861-B | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-113993861-A | Phenylethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2022-01-28 | — | — | CN | disclosed |
| WO-2020207414-A1 | BENZETHERS AND ANILINES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2020-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024503-B2 | Benzethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof | JAK3, JAK1, JAK2 | TBK1 70/4885IKBKE 317/4885LRRK2 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.