Sugi Predict

Sugi Predict / Compounds / SCHEMBL22553835

SCHEMBL22553835

SCHEMBL22553835

CN(C)S(=O)(=O)c1cnc2c(c1)c(-c1cncc(-c3ccc(N4CCCC4=O)cc3)c1)cn2C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.39
▸ BRD4 O60885 1/20 0.39
▸ BRDT Q58F21 1/20 0.39
▸ NPC1 O15118 2/20 0.37
▸ PIP4K2A P48426 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ CCNC P24863 2/20 0.36
▸ CDK8 P49336 2/20 0.36
▸ PKM P14618 1/20 0.36
▸ TSHR P16473 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ CD38 P28907 1/20 0.35
▸ KIT P10721 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ AKR1C3 P42330 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SYK P43405 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22554063 0.86 BRD4 (0.45) HTTBRD4BRDTNPC1PIP4K2A
SCHEMBL22553785 0.83 CYP11B2 (0.45) BRD4BRDTNPC1PIP4K2ASMN1; SMN2
SCHEMBL22553730 0.83 DYRK1A (0.40) HTTNPC1SMN1; SMN2PKMGAA
SCHEMBL22553891 0.83 BRD4 (0.44) BRD4BRDTNPC1PIP4K2ACCNC
SCHEMBL30730819 0.82 BRD4 (0.43) BRD4BRDTNPC1PIP4K2ACCNC
SCHEMBL22554125 0.82 BRD4 (0.43) BRD4BRDTNPC1PIP4K2ACCNC
SCHEMBL22553729 0.82 BRD4 (0.43) BRD4BRDTNPC1PIP4K2ACCNC
SCHEMBL22553919 0.82 PIP4K2A (0.46) BRD4BRDTNPC1PIP4K2ACCNC
SCHEMBL22553754 0.82 BRD4 (0.49) BRD4BRDTNPC1PIP4K2ACCNC
SCHEMBL30730836 0.82 PIP4K2A (0.46) BRD4BRDTNPC1PIP4K2ACCNC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors HIBERCELL, INC. (US) 2024-03-05 — — US claimed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US claimed
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors HIBERCELL, INC. (US) 2024-03-05 — — US disclosed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US disclosed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS PIP5K1A, PIP5K1B, PIP5K1C HTT 1981/4885BRD4 309/4885BRDT 786/4885
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors PIP5K1A, PIP5K1B, PIP5K1C HTT 1981/4885BRD4 309/4885BRDT 786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.