Sugi Predict

Sugi Predict / Compounds / SCHEMBL22553869

SCHEMBL22553869

SCHEMBL22553869

CN(C)C(=O)c1cc2c(-c3cncc(-c4ccc(N5CCCC5=O)cc4)c3)cn(C)c2c(=O)n1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 1/20 0.41
▸ BRDT Q58F21 1/20 0.41
▸ NPC1 O15118 1/20 0.37
▸ CYP11B2 P19099 2/20 0.37
▸ CCNC P24863 2/20 0.35
▸ CDK8 P49336 2/20 0.35
▸ CHEK1 O14757 1/20 0.35
▸ IP6K1 Q92551 1/20 0.35
▸ IP6K3 Q96PC2 1/20 0.35
▸ IP6K2 Q9UHH9 1/20 0.35
▸ PHGDH O43175 1/20 0.35
▸ GALR3 O60755 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.34
▸ HPGD P15428 2/20 0.34
▸ PRKAB2 O43741 1/20 0.34
▸ PRKAG1 P54619 1/20 0.34
▸ PRKAA2 P54646 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22553848 0.90 BRD4 (0.42) BRD4BRDTNPC1CYP11B2CCNC
SCHEMBL22554064 0.88 NPC1 (0.41) BRD4BRDTNPC1CYP11B2CCNC
SCHEMBL22571017 0.87 CHEK1 (0.38) BRD4CYP11B2CHEK1HTTALDH1A1
SCHEMBL22553779 0.81 BRD4 (0.47) BRD4BRDTNPC1CYP11B2CCNC
SCHEMBL22553785 0.80 CYP11B2 (0.45) BRD4BRDTNPC1CYP11B2CCNC
SCHEMBL22554295 0.77 BRD4 (0.48) BRD4BRDTNPC1CCNCCDK8
SCHEMBL22553979 0.77 BRD4 (0.48) BRD4BRDTNPC1CYP11B2CCNC
SCHEMBL22554063 0.74 BRD4 (0.45) BRD4BRDTNPC1CYP11B2CCNC
SCHEMBL22553754 0.74 BRD4 (0.49) BRD4BRDTNPC1CYP11B2CCNC
SCHEMBL22553919 0.74 PIP4K2A (0.46) BRD4BRDTNPC1CYP11B2CCNC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors HIBERCELL, INC. (US) 2024-03-05 — — US claimed
EP-3728230-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS Ravenna Pharmaceuticals, Inc. (US) 2020-10-28 — — EP claimed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US claimed
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors HIBERCELL, INC. (US) 2024-03-05 — — US disclosed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US disclosed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS PIP5K1A, PIP5K1B, PIP5K1C BRD4 309/4885BRDT 786/4885NPC1 1648/4885
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors PIP5K1A, PIP5K1B, PIP5K1C BRD4 309/4885BRDT 786/4885NPC1 1648/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.