Sugi Predict

Sugi Predict / Compounds / SCHEMBL22553972

SCHEMBL22553972

SCHEMBL22553972

Cn1cc(-c2cncnc2)c2cc(Cl)cnc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ MEN1 O00255 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ PABPC1 P11940 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ CYP17A1 P05093 2/20 0.34
▸ CYP11B1 P15538 2/20 0.34
▸ CYP11B2 P19099 2/20 0.34
▸ PDK1 Q15118 4/20 0.33
▸ NTRK1 P04629 2/20 0.33
▸ HSP90AA1 P07900 1/20 0.33
▸ HSP90AB1 P08238 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ PDE10A Q9Y233 4/20 0.33
▸ IDH1 O75874 1/20 0.33
▸ NFATC1 O95644 1/20 0.33
▸ GSK3B P49841 1/20 0.33
▸ DYRK1A Q13627 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22554117 0.83 CYP2A6 (0.44) CYP17A1CYP11B1CYP11B2CYP3A4PDE10A
SCHEMBL22553855 0.75 HPGD (0.35) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL18540666 0.74 HPGD (0.43) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL22553853 0.73 HSD17B10 (0.37) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL15384517 0.72 HSD17B10 (0.42) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL30731040 0.72 HSD17B10 (0.42) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL22151215 0.72 HPGD (0.42) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL22150189 0.70 HPGD (0.40) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL18538046 0.70 HPGD (0.40) HPGDHTTHSD17B10MEN1LMNA
SCHEMBL18629344 0.70 PDK1 (0.34) HPGDHTTHSD17B10MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors HIBERCELL, INC. (US) 2024-03-05 — — US disclosed
CN-112088157-B Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors 拉文纳制药公司 2023-12-26 — — CN disclosed
CN-112088157-A Aryl-bipyridine amine derivatives as phosphoinositide kinase inhibitors 拉文纳制药公司 2020-12-15 — — CN disclosed
EP-3728230-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS Ravenna Pharmaceuticals, Inc. (US) 2020-10-28 — — EP disclosed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US disclosed
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS HIBERCELL, INC. 2020-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200331913-A1 ARYL-BIPYRIDINE AMINE DERIVATIVES AS PHOSPHATIDYLINOSITOL PHOSPHATE KINASE INHIBITORS PIP5K1A, PIP5K1B, PIP5K1C HPGD 3902/4885HTT 1981/4885HSD17B10 3839/4885
US-11919902-B2 Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors PIP5K1A, PIP5K1B, PIP5K1C HPGD 3902/4885HTT 1981/4885HSD17B10 3839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.