Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL5272119 | 0.84 | ALDH1A1 (0.74) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL2201840 | 0.84 | ALDH1A1 (0.74) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL1287895 | 0.84 | ALDH1A1 (0.74) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL27782946 | 0.82 | ALDH1A1 (0.71) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL28169251 | 0.80 | ALDH1A1 (0.68) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL28043625 | 0.80 | ALDH1A1 (0.74) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL28043624 | 0.80 | ALDH1A1 (0.74) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL8318250 | 0.80 | ALDH1A1 (0.81) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL28169361 | 0.79 | ALDH1A1 (0.65) | ALDH1A1NPC1KDM4EMEN1MAPT | |
| Quinoline SCHEMBL27864428 | 0.78 | ALDH1A1 (0.71) | ALDH1A1NPC1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125724-B1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK CANADA INC (CA) | 2014-12-03 | — | — | EP | disclosed |
| CN-101636385-B | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK FROSST CANADA LTD | 2012-09-05 | — | — | CN | disclosed |
| CN-101636385-B | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK FROSST CANADA LTD | 2012-09-05 | — | — | CN | disclosed |
| CN-101636385-B | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK FROSST CANADA LTD | 2012-09-05 | — | — | CN | disclosed |
| US-8003661-B2 | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK CANADA INC. (CA) | 2011-08-23 | — | — | US | disclosed |
| US-8003661-B2 | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK CANADA INC. (CA) | 2011-08-23 | — | — | US | disclosed |
| US-8003661-B2 | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK CANADA INC. (CA) | 2011-08-23 | — | — | US | disclosed |
| US-20100105718-A1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2010-04-29 | — | — | US | disclosed |
| US-20100105718-A1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2010-04-29 | — | — | US | disclosed |
| CN-101636385-A | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK FROSST CANADA LTD | 2010-01-27 | — | — | CN | disclosed |
| CN-101636385-A | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK FROSST CANADA LTD | 2010-01-27 | — | — | CN | disclosed |
| CN-101636385-A | Naphthalene and quinoline sulfonylurea derivatives as EP4 receptor antagonists | MERCK FROSST CANADA LTD | 2010-01-27 | — | — | CN | disclosed |
| EP-2125724-A1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Merck Frosst Canada Ltd. (CA) | 2009-12-02 | — | — | EP | disclosed |
| EP-2125724-A1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Merck Frosst Canada Ltd. (CA) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008116304-A1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008116304-A1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2008-10-02 | — | — | WO | disclosed |
| EP-0711112-A1 | HERBICIDE COMPOSITION, ACTIVITY-PROMOTING AGENT FOR IMPROVING THE EFFICACY OF THE HERBICIDE, AND A METHOD FOR TREATING CULTIVATED PLANTS | KEMIRA OY (FI) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995003697-A1 | HERBICIDE COMPOSITION, ACTIVITY-PROMOTING AGENT FOR IMPROVING THE EFFICACY OF THE HERBICIDE, AND A METHOD FOR TREATING CULTIVATED PLANTS | KEMIRA OY (FI) | 1995-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105718-A1 | NAPHTHALENE AND QUINOLINE SULFONYLUREA DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | PTGER4, P2RY4, PTGER1 | ALDH1A1 1376/4885NPC1 1028/4885KDM4E 1884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.