Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 4/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22556796 | 0.84 | DDB1 (0.44) | CRBNDDB1IKZF3 | |
| SCHEMBL22557788 | 0.81 | CRBN (0.49) | CRBNDDB1IKZF3 | |
| SCHEMBL3654403 | 0.73 | CRBN (0.57) | CRBNDDB1IKZF3 | |
| SCHEMBL24132069 | 0.72 | CRBN (0.54) | CRBNDDB1IKZF3 | |
| SCHEMBL31554634 | 0.70 | DDB1 (0.49) | CRBNDDB1IKZF3 | |
| SCHEMBL19586175 | 0.69 | CRBN (0.76) | CRBNDDB1IKZF3 | |
| SCHEMBL3655337 | 0.69 | CRBN (0.57) | CRBNDDB1IKZF3 | |
| SCHEMBL30900754 | 0.69 | CRBN (0.49) | CRBNDDB1IKZF3 | |
| SCHEMBL27239115 | 0.69 | CRBN (0.49) | CRBNDDB1IKZF3 | |
| SCHEMBL16221485 | 0.68 | CRBN (0.56) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020211822-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | 成都海创药业有限公司 | 2020-10-22 | — | — | WO | disclosed |