Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 14/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22556796 | 0.81 | DDB1 (0.44) | CRBNDDB1IKZF3 | |
| SCHEMBL22557583 | 0.81 | CRBN (0.41) | CRBNDDB1IKZF3 | |
| SCHEMBL31612876 | 0.77 | CRBN (0.66) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL3654403 | 0.77 | CRBN (0.57) | CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL19586175 | 0.77 | CRBN (0.76) | CRBNDDB1IKZF3 | |
| SCHEMBL3655337 | 0.77 | CRBN (0.57) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL31554731 | 0.77 | CRBN (0.57) | CRBNDDB1IKZF3ALDH1A1 | |
| SCHEMBL30702624 | 0.76 | CRBN (0.55) | CRBNDDB1IKZF3USP2ALDH1A1 | |
| SCHEMBL24132069 | 0.74 | CRBN (0.54) | CRBNDDB1IKZF3ALDH1A1CYP1A2 | |
| SCHEMBL16221485 | 0.74 | CRBN (0.56) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020211822-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | 成都海创药业有限公司 | 2020-10-22 | — | — | WO | disclosed |
| WO-2020211822-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | 成都海创药业有限公司 | 2020-10-22 | — | — | WO | disclosed |