Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 18/20 | 0.52 |
| ▸ | CDK4 | P11802 | 17/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.52 |
| ▸ | CDK2 | P24941 | 6/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.52 |
| ▸ | CDK9 | P50750 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CCND3 | P30281 | 13/20 | 0.47 |
| ▸ | CCND2 | P30279 | 6/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22566529 | 0.88 | PIK3CA (0.49) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL19021561 | 0.85 | CDK4 (0.66) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL22553551 | 0.84 | CDK4 (0.48) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL22553515 | 0.76 | CDK4 (0.83) | CCND1CDK4CDK6CCND3 | |
| SCHEMBL22566623 | 0.74 | PIK3CA (0.49) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL22553600 | 0.73 | CDK4 (0.39) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL4137710 | 0.72 | PIK3CA (0.40) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL22557914 | 0.71 | CDK4 (0.41) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL22553522 | 0.71 | CDK4 (0.41) | CCND1CDK4CDK6CDK2CCNE1 | |
| SCHEMBL19294159 | 0.71 | CDK4 (0.64) | CCND1CDK4CDK6CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956031-A1 | ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH | Pfizer Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| CN-114007697-A | Antiproliferative agents for the treatment of PAH | 辉瑞公司 | 2022-02-01 | — | — | CN | disclosed |
| WO-2020212865-A1 | ANTI-PROLIFERATIVE AGENTS FOR TREATING PAH | PFIZER INC. (US) | 2020-10-22 | — | — | WO | disclosed |