Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.36 |
| ▸ | CDK2 | P24941 | 7/20 | 0.36 |
| ▸ | CCND1 | P24385 | 6/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4153889 | 0.86 | CCNE1 (0.46) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL4147585 | 0.85 | PIK3CA (0.38) | PIK3CADYRK1AEGFRBRD4TNK2 | |
| SCHEMBL3669389 | 0.83 | CCNE1 (0.61) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL4722727 | 0.82 | CCNE1 (0.49) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL3673605 | 0.82 | CCNE1 (0.49) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL3669287 | 0.82 | CCNE1 (0.49) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL4147310 | 0.82 | MAPK14 (0.44) | PIK3CACCNE1CDK2CCND1CDK6 | |
| SCHEMBL4157046 | 0.81 | DRD2 (0.42) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL4151475 | 0.81 | PIK3CA (0.43) | PIK3CACCNE1CDK2CCND1CDK6 | |
| SCHEMBL3680091 | 0.81 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221600-A1 | PYRIDO-PYRIDIMIDINE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221600-A1 | PYRIDO-PYRIDIMIDINE DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | PNPO, TPMT, NOD1 | PIK3CA 473/4885DYRK1A 2814/4885EGFR 3067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.