Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | AHR | P35869 | 3/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | WNT3A | P56704 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29399389 | 1.00 | MEN1 (0.62) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL22644159 | 0.89 | MEN1 (0.63) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL23551201 | 0.88 | KMT2A (0.65) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL21547837 | 0.84 | MEN1 (0.58) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL24706859 | 0.84 | MEN1 (0.58) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL29396458 | 0.83 | MEN1 (0.44) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL22559142 | 0.83 | MEN1 (0.44) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL22644186 | 0.83 | MEN1 (0.66) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL21366393 | 0.82 | MEN1 (0.69) | MEN1MAPTKMT2AAHRNR1I2 | |
| SCHEMBL21366240 | 0.81 | MEN1 (0.74) | MEN1MAPTKMT2AAHRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389002-A1 | Chiral Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2022-12-08 | — | — | US | disclosed |
| US-20220389002-A1 | Chiral Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2022-12-08 | — | — | US | disclosed |
| US-11390621-B2 | Chiral indole compounds and their use | ARIAGEN, INC. (US) | 2022-07-19 | — | — | US | disclosed |
| EP-3956327-A1 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | Ariagen, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20210188834-A1 | Chiral Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2021-06-24 | — | — | US | disclosed |
| US-20210188834-A1 | Chiral Indole Compounds and Their Use | ARIAGEN, INC. (US) | 2021-06-24 | — | — | US | disclosed |
| WO-2020214740-A9 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | ARIAGEN, INC. (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2020214740-A9 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | ARIAGEN, INC. (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2020214740-A1 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | ARIAGEN, INC. (US) | 2020-10-22 | — | — | WO | disclosed |
| WO-2020214740-A1 | CHIRAL INDOLE COMPOUNDS AND THEIR USE | ARIAGEN, INC. (US) | 2020-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188834-A1 | Chiral Indole Compounds and Their Use | IDO1, IDO2, INMT | MEN1 2509/4885MAPT 2397/4885KMT2A 1577/4885 |
| US-20220389002-A1 | Chiral Indole Compounds and Their Use | IDO1, IDO2, INMT | MEN1 2509/4885MAPT 2397/4885KMT2A 1577/4885 |
| US-11390621-B2 | Chiral indole compounds and their use | IDO1, IDO2, INMT | MEN1 2509/4885MAPT 2397/4885KMT2A 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.