Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | EED | O75530 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.50 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.50 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15700396 | 0.87 | EZH2 (0.78) | EZH2HDAC1HDAC6NR1I2EED | |
| SCHEMBL15700394 | 0.82 | EZH2 (0.75) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL20612508 | 0.81 | EZH2 (0.77) | EZH2HDAC1HDAC6EEDRBBP4 | |
| SCHEMBL18715273 | 0.81 | EZH2 (0.74) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL24224510 | 0.81 | EZH2 (0.80) | EZH2HDAC1HDAC6 | |
| SCHEMBL24224552 | 0.79 | EZH2 (0.75) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL21689386 | 0.79 | EZH2 (0.56) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL24224584 | 0.79 | EZH2 (0.75) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL18715250 | 0.79 | EZH2 (0.75) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL24224545 | 0.79 | EZH2 (0.78) | EZH2NR1I2EEDABCB11PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725314-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |