Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | EED | O75530 | 2/20 | 0.54 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.54 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.54 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.50 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.50 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.50 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21914671 | 0.91 | EZH2 (0.65) | EZH2HDAC1HDAC6EEDRBBP4 | |
| SCHEMBL24224510 | 0.88 | EZH2 (0.80) | EZH2HDAC1HDAC6 | |
| SCHEMBL13280847 | 0.87 | EZH2 (1.00) | EZH2HDAC1HDAC6EEDRBBP4 | |
| SCHEMBL24224497 | 0.87 | EZH2 (0.76) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL24224571 | 0.86 | EZH2 (0.64) | EZH2HDAC1HDAC6EZH1 | |
| SCHEMBL30688044 | 0.82 | EZH2 (1.00) | EZH2HDAC1HDAC6EEDRBBP4 | |
| SCHEMBL13277257 | 0.82 | EZH2 (1.00) | EZH2HDAC1HDAC6EEDRBBP4 | |
| SCHEMBL18715186 | 0.82 | EZH2 (0.57) | EZH2 | |
| SCHEMBL19503337 | 0.82 | EZH2 (0.55) | EZH2HDAC1HDAC6EEDRBBP4 | |
| SCHEMBL22561478 | 0.81 | EZH2 (0.59) | EZH2HDAC1HDAC6EEDRBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2825161-B1 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2019-01-02 | — | — | EP | disclosed |