Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY1 | Q08828 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 6/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RHOA | P61586 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009149 | 0.69 | RAF1 (0.41) | MAPTRAF1BRAF | |
| SCHEMBL23677290 | 0.65 | MEN1 (0.46) | MEN1KMT2ACYP1A2CYP3A4MAPT | |
| SCHEMBL25739849 | 0.64 | SMN1; SMN2 (0.62) | MEN1KMT2ACYP1A2CYP3A4MAPT | |
| SCHEMBL20009394 | 0.60 | BRAF (0.70) | MAPK14RAF1BRAF | |
| SCHEMBL14305900 | 0.60 | LDLR (0.38) | MAPK14 | |
| SCHEMBL26949118 | 0.57 | ABL1 (0.46) | ABL1MEN1KMT2A | |
| SCHEMBL22490321 | 0.57 | MAPK14 (0.59) | ABL1MAPK14CYP2C9RAF1 | |
| SCHEMBL1990577 | 0.56 | — | — | |
| SCHEMBL1990574 | 0.56 | — | — | |
| SCHEMBL29536688 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191467-B1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2020-10-21 | — | — | EP | disclosed |