SCHEMBL22562373

SCHEMBL22562373

N#Cc1cc(-n2c3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)cc3c3cc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)ccc32)c(-c2cccc(-c3ccccc3)n2)c(-n2c3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)cc3c3cc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)ccc32)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.38
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
SCN9A Q15858 5/20 0.35
CYP2C9 P11712 1/20 0.35
PDK2 Q15119 1/20 0.34
EDNRB P24530 1/20 0.34
EDNRA P25101 1/20 0.34
MAT2A P31153 1/20 0.34
TRPV3 Q8NET8 2/20 0.34
ALDH1A1 P00352 3/20 0.33
TDP1 Q9NUW8 3/20 0.33
KDM4E B2RXH2 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
ACP1 P24666 1/20 0.33
AR P10275 1/20 0.32
XDH P47989 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562372 0.93 CTSS (0.38) CTSSALOX5APFEN1SCN9ACYP2C9
SCHEMBL19909444 0.92 ALOX5AP (0.36) CTSSALOX5APFEN1SCN9ACYP2C9
SCHEMBL22562460 0.91 ALOX5AP (0.39) ALOX5APFEN1SCN9ACYP2C9EDNRB
SCHEMBL22563580 0.90 ALOX5AP (0.36) ALOX5APFEN1SCN9ACYP2C9EDNRB
SCHEMBL19919476 0.90 ALOX5AP (0.34) ALOX5APFEN1SCN9ACYP2C9EDNRB
SCHEMBL22562419 0.89 CYP2C9 (0.37) CTSSALOX5APFEN1SCN9ACYP2C9
SCHEMBL21898637 0.88 CTSS (0.40) CTSSSCN9ACYP2C9MAT2AALDH1A1
SCHEMBL22563407 0.88 ALOX5AP (0.34) ALOX5APFEN1SCN9ACYP2C9EDNRB
SCHEMBL21109711 0.87 S1PR1 (0.34) ALOX5APFEN1SCN9ACYP2C9EDNRB
SCHEMBL22562527 0.87 CTSS (0.39) CTSSALOX5APFEN1SCN9ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed