SCHEMBL22562376

SCHEMBL22562376

N#Cc1c(-n2c3ccccc3c3cc(-c4nc(-c5ccccc5)nc(-c5ccccc5)n4)ccc32)cc(-c2cccc(-c3ccccc3)n2)cc1-n1c2ccccc2c2cc(-c3nc(-c4ccccc4)nc(-c4ccccc4)n3)ccc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.36
ADORA1 P30542 3/20 0.36
HSD17B10 Q99714 2/20 0.36
MEN1 O00255 7/20 0.35
KMT2A Q03164 7/20 0.35
ALDH1A1 P00352 5/20 0.35
LMNA P02545 3/20 0.35
CYP1A2 P05177 3/20 0.35
CYP3A4 P08684 3/20 0.35
CYP2C19 P33261 2/20 0.35
CLK4 Q9HAZ1 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C9 P11712 1/20 0.35
TSHR P16473 1/20 0.35
SQOR Q9Y6N5 3/20 0.35
RAB9A P51151 2/20 0.35
HPGD P15428 4/20 0.35
MAPT P10636 2/20 0.35
KDM4E B2RXH2 2/20 0.34
MAPK1 P28482 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562283 0.97 ADORA1 (0.39) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL22562529 0.94 ADORA2A (0.36) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL21278726 0.93 MEN1 (0.42) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL19909547 0.92 SQOR (0.38) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL22563390 0.91 MEN1 (0.42) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL19942789 0.91 ADORA1 (0.38) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL22562377 0.90 ADORA1 (0.39) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL21278785 0.90 MEN1 (0.44) ADORA2AADORA1HSD17B10MEN1KMT2A
SCHEMBL23296423 0.90 KMT2A (0.43) ADORA2AADORA1MEN1KMT2AALDH1A1
SCHEMBL31273346 0.90 KMT2A (0.43) ADORA2AADORA1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed