SCHEMBL22562385

SCHEMBL22562385

N#Cc1cc(C#N)cc(-c2ccc3c4ccccc4n(-c4cc(-c5cccc(-c6ccccc6)n5)cc(-n5c6ccccc6c6ccc(-c7cc(C#N)cc(C#N)c7)cc65)c4C#N)c3c2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 1/20 0.39
ADORA2A P29274 5/20 0.37
ADORA1 P30542 5/20 0.37
GABRA1 P14867 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
ADORA2B P29275 3/20 0.35
MYC P01106 1/20 0.35
SQOR Q9Y6N5 3/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HIF1A Q16665 1/20 0.33
PGR P06401 1/20 0.33
CFTR P13569 1/20 0.33
RAB9A P51151 1/20 0.33
GRM5 P41594 1/20 0.33
MAPK1 P28482 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562366 0.97 ALDH1A3 (0.41) ALDH1A3ADORA2AADORA1GABRA1GABRG2
SCHEMBL22562365 0.94 ALDH1A3 (0.39) ALDH1A3ADORA2AADORA1GABRA1GABRG2
SCHEMBL22562398 0.93 MYC (0.40) ALDH1A3ADORA2AADORA1GABRA1GABRG2
SCHEMBL22760804 0.90 ALDH1A3 (0.46) ALDH1A3ADORA2AADORA1GABRA1GABRG2
SCHEMBL22562530 0.90 ALDH1A3 (0.41) ALDH1A3ADORA2AADORA1GABRA1GABRG2
SCHEMBL22562529 0.89 ADORA2A (0.36) ADORA2AADORA1SQORMEN1KMT2A
SCHEMBL22562394 0.89 MYC (0.42) ALDH1A3ADORA2AADORA1GABRA1GABRG2
SCHEMBL22562523 0.89 MEN1 (0.40) ALDH1A3ADORA2AADORA1SQORMEN1
SCHEMBL22562258 0.88 ALDH1A3 (0.40) ALDH1A3ADORA2AGABRA1GABRG2GABRB3
SCHEMBL21546840 0.88 ADORA2A (0.37) ALDH1A3ADORA2AADORA1GABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed