SCHEMBL22562397

SCHEMBL22562397

N#Cc1ccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(-c3cccc(-c4ccccc4)n3)cc(-n3c4ccccc4c4cc(-c5ccc(C#N)cc5)ccc43)c2C#N)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MYC P01106 1/20 0.40
ALDH1A3 P47895 2/20 0.40
GABRA1 P14867 2/20 0.39
GABRG2 P18507 2/20 0.39
GABRB3 P28472 2/20 0.39
GABRA5 P31644 2/20 0.39
GABRA3 P34903 2/20 0.39
ABCG2 Q9UNQ0 2/20 0.38
ABCB1 P08183 1/20 0.38
PTGER4 P35408 1/20 0.38
ADORA2A P29274 4/20 0.36
ADORA1 P30542 3/20 0.36
NPY5R Q15761 1/20 0.35
HSD11B1 P28845 1/20 0.35
SQOR Q9Y6N5 1/20 0.34
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562395 0.97 MYC (0.42) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL22562398 0.94 MYC (0.40) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL22562182 0.93 PTGER4 (0.35) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL22562365 0.93 ALDH1A3 (0.39) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL19909205 0.93 MYC (0.48) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL22562515 0.92 ADORA2A (0.40) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL22562522 0.92 MEN1 (0.40) ALDH1A3ADORA2AADORA1SQORKDM4E
SCHEMBL21279093 0.91 ABCG2 (0.43) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL22562394 0.90 MYC (0.42) MYCALDH1A3GABRA1GABRG2GABRB3
SCHEMBL22562530 0.89 ALDH1A3 (0.41) MYCALDH1A3GABRA1GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed