SCHEMBL22562582

SCHEMBL22562582

N#Cc1cc(-n2c3ccccc3c3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)cc32)c(-n2c3ccccc3c3ccc(-c4ccc(C(F)(F)F)cc4C(F)(F)F)cc32)cc1-c1cccc(-c2ccccc2)n1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.36
XDH P47989 1/20 0.36
ALOX5AP P20292 2/20 0.36
FEN1 P39748 2/20 0.36
AR P10275 4/20 0.35
SCN9A Q15858 5/20 0.34
CYP2C9 P11712 1/20 0.34
EDNRB P24530 1/20 0.33
EDNRA P25101 1/20 0.33
KIF11 P52732 1/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
GAA P10253 1/20 0.32
HPGD P15428 1/20 0.32
PGR P06401 1/20 0.32
CYP11B2 P19099 1/20 0.32
CNR2 P34972 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562606 0.95 CTSS (0.36) CTSSXDHALOX5APFEN1AR
SCHEMBL19919798 0.92 ALOX5AP (0.36) XDHALOX5APFEN1ARSCN9A
SCHEMBL22562346 0.92 CTSS (0.38) CTSSXDHALOX5APFEN1AR
SCHEMBL22562450 0.91 ALOX5AP (0.37) ALOX5APFEN1SCN9ACYP2C9EDNRB
SCHEMBL22562423 0.91 CTSS (0.41) CTSSXDHALOX5APFEN1SCN9A
SCHEMBL21278848 0.91 ALOX5AP (0.35) XDHALOX5APFEN1ARSCN9A
SCHEMBL22563411 0.90 ALOX5AP (0.36) XDHALOX5APFEN1ARSCN9A
SCHEMBL19919642 0.89 AR (0.36) CTSSXDHALOX5APFEN1AR
SCHEMBL20111614 0.88 AR (0.41) XDHALOX5APFEN1ARSCN9A
SCHEMBL22562428 0.88 CTSS (0.44) CTSSXDHALOX5APFEN1SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed