SCHEMBL22562586

SCHEMBL22562586

Cc1ccc(-c2ccc3c(c2)c2cc(-c4ccc(C)cc4C)ccc2n3-c2cc(C#N)cc(-n3c4ccc(-c5ccc(C)cc5C)cc4c4cc(-c5ccc(C)cc5C)ccc43)c2-c2cccc(-c3ccccc3)n2)c(C)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.38
ADORA1 P30542 2/20 0.38
KDM4E B2RXH2 4/20 0.36
NPSR1 Q6W5P4 2/20 0.36
HPGD P15428 1/20 0.36
PPARG P37231 1/20 0.36
NCOA2 Q15596 1/20 0.36
NCOA1 Q15788 1/20 0.36
NCOA3 Q9Y6Q9 1/20 0.36
ALDH1A3 P47895 2/20 0.35
MAPT P10636 3/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
THRB P10828 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
TGFBR1 P36897 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
MYC P01106 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562585 0.92 ADORA2A (0.38) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL19909415 0.91 KDM4E (0.41) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL21278852 0.90 HPGD (0.38) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL22563578 0.89 KDM4E (0.39) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL19909172 0.89 KDM4E (0.39) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL22562576 0.87 PTGER4 (0.35) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL21278807 0.87 HPGD (0.36) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL22563367 0.87 ADORA2A (0.37) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL21109679 0.86 ABCG2 (0.36) ADORA2AADORA1KDM4ENPSR1HPGD
SCHEMBL22562583 0.86 ALDH1A3 (0.39) ADORA2AADORA1KDM4ENPSR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed