Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315932 | 0.91 | MEN1 (0.57) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL749352 | 0.90 | GRM5 (0.54) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL15747743 | 0.88 | LNPEP (0.54) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL21384574 | 0.86 | TDP1 (0.50) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL25201639 | 0.86 | NAMPT (0.50) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL22551192 | 0.85 | GRM5 (0.48) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL22551243 | 0.84 | LNPEP (0.49) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL6395476 | 0.84 | NPC1 (0.53) | GRM5LNPEPSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29087403 | 0.84 | MEN1 (0.54) | GRM5LNPEPMEN1KMT2ANPSR1 | |
| SCHEMBL29995210 | 0.84 | MEN1 (0.54) | GRM5LNPEPMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3725777-A1 | BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | Rottapharm Biotech S.r.l. (IT) | 2020-10-21 | — | — | EP | disclosed |