Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22565974 | 0.89 | CYP3A4 (0.35) | OPRL1OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL22565088 | 0.85 | OPRM1 (0.32) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL22565052 | 0.84 | HRH3 (0.34) | OPRL1OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL24196417 | 0.82 | OPRL1 (0.33) | OPRL1OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL24197067 | 0.82 | OPRL1 (0.33) | OPRL1OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL24197069 | 0.82 | OPRL1 (0.33) | OPRL1OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL22565161 | 0.82 | OPRL1 (0.33) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL22565128 | 0.82 | HRH3 (0.40) | OPRL1OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL26743370 | 0.81 | HRH3 (0.33) | HRH3 | |
| SCHEMBL25508639 | 0.80 | OPRL1 (0.32) | OPRL1OPRM1OPRD1OPRK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3957633-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | Hinova Pharmaceuticals Inc. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211822-A1 | A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF | 成都海创药业有限公司 | 2020-10-22 | — | — | WO | disclosed |