SCHEMBL22565087

SCHEMBL22565087

CN1CCC(N2CCC3(CC2)CN(C)C3)CC1

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 4/20 0.36
ALDH1A1 P00352 2/20 0.36
L3MBTL3 Q96JM7 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PIM1 P11309 1/20 0.32
NCF1 P14598 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM3 P20309 1/20 0.31
GAA P10253 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1753855 0.91 HRH3 (0.38) HRH3
SCHEMBL22565134 0.90 ALDH1A1 (0.35) HRH3ALDH1A1L3MBTL3L3MBTL1PIM1
SCHEMBL22565062 0.88 HRH3 (0.32) HRH3ALDH1A1
SCHEMBL22565120 0.88 ALDH1A1 (0.38) HRH3ALDH1A1L3MBTL3L3MBTL1
SCHEMBL14996489 0.87 ALDH1A1 (0.38) HRH3ALDH1A1L3MBTL3L3MBTL1PIM1
SCHEMBL22565061 0.85 ALDH1A1 (0.41) HRH3ALDH1A1L3MBTL3L3MBTL1NCF1
SCHEMBL24480872 0.83 HRH3 (0.33) HRH3L3MBTL3L3MBTL1
SCHEMBL22565119 0.83 ALDH1A1 (0.40) HRH3ALDH1A1L3MBTL3L3MBTL1NCF1
SCHEMBL24996228 0.83 ALDH1A1 (0.42) HRH3ALDH1A1L3MBTL3L3MBTL1PIM1
SCHEMBL25820246 0.83 ALDH1A1 (0.42) ALDH1A1L3MBTL3L3MBTL1PIM1NCF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3957633-A1 A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF Hinova Pharmaceuticals Inc. (CN) 2022-02-23 EP disclosed
WO-2022002100-A1 NOVEL BENZIMIDAZOLE COMPOUND 微境生物医药科技(上海)有限公司 2022-01-06 WO disclosed
WO-2020211822-A1 A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF 成都海创药业有限公司 2020-10-22 WO disclosed