Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.57 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | ATR | Q13535 | 6/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | BCR | P11274 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ABL2 | P42684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573826 | 0.89 | KCNK3 (0.53) | IRAK4IDEKMT2ABRAFATR | |
| SCHEMBL22573633 | 0.89 | MEN1 (0.58) | KMT2AATR | |
| SCHEMBL22573788 | 0.88 | KMT2A (0.60) | IDEKMT2AATRABL1BCR | |
| SCHEMBL22573921 | 0.87 | PRKCI (0.56) | KMT2AATRCYP3A4 | |
| SCHEMBL22573435 | 0.87 | ATR (0.67) | BRAFATRCSF1RABL1BCR | |
| SCHEMBL22573490 | 0.86 | ATR (0.63) | IRAK4KMT2AATRCYP3A4 | |
| SCHEMBL22573417 | 0.85 | KMT2A (0.59) | IDEKMT2ACYP3A4 | |
| SCHEMBL22573831 | 0.84 | ATR (0.64) | KMT2AATR | |
| SCHEMBL22573298 | 0.81 | KMT2A (0.52) | IDEKMT2AATRCYP3A4 | |
| SCHEMBL22573399 | 0.81 | POLB (0.55) | IDEKMT2AATRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | claimed |
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |