Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ATR | Q13535 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573831 | 0.93 | ATR (0.64) | MEN1KMT2AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22573826 | 0.91 | KCNK3 (0.53) | MEN1KMT2AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22573589 | 0.89 | IRAK4 (0.57) | KMT2AATR | |
| SCHEMBL22573719 | 0.86 | LMNA (0.62) | MEN1KMT2AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22573773 | 0.86 | LMNA (0.62) | MEN1KMT2AALDH1A1LMNAATR | |
| SCHEMBL22573436 | 0.86 | MEN1 (0.59) | MEN1KMT2AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22573428 | 0.85 | MEN1 (0.50) | MEN1KMT2AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22573804 | 0.82 | ATM (0.58) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL22573661 | 0.81 | RAB9A (0.54) | MEN1KMT2AALDH1A1ATRSMN1; SMN2 | |
| SCHEMBL22573458 | 0.81 | ATR (0.64) | MEN1KMT2AALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | claimed |
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |