Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | GRK5 | P34947 | 1/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573768 | 0.88 | ADORA2A (0.65) | ADORA3ADORA2AADORA2BADORA1CHEK1 | |
| SCHEMBL22573408 | 0.84 | ADORA3 (0.60) | ADORA3ADORA2AADORA2BADORA1BTK | |
| SCHEMBL22573464 | 0.84 | ADORA2A (0.57) | ADORA3ADORA2AADORA2BADORA1BTK | |
| SCHEMBL22573625 | 0.84 | ADORA3 (0.60) | ADORA3ADORA2AADORA2BADORA1BTK | |
| SCHEMBL22573501 | 0.84 | ADORA3 (0.60) | ADORA3ADORA2AADORA2BADORA1KMT2A | |
| SCHEMBL22574015 | 0.84 | ADORA3 (0.63) | ADORA3ADORA2AADORA2BADORA1KMT2A | |
| SCHEMBL22573335 | 0.84 | ADORA2A (0.59) | ADORA3ADORA2AADORA2BADORA1BTK | |
| SCHEMBL22573626 | 0.83 | ADORA3 (0.58) | ADORA3ADORA2AADORA2BADORA1KMT2A | |
| SCHEMBL22573609 | 0.82 | ADORA2A (0.66) | ADORA3ADORA2AADORA2BADORA1BTK | |
| SCHEMBL22573552 | 0.81 | ADORA2A (0.66) | ADORA3ADORA2AADORA2BADORA1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | claimed |
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | disclosed |