Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22573626 | 0.84 | ADORA3 (0.58) | ADORA3ADORA2AADORA2BADORA1HSD17B10 | |
| SCHEMBL22573609 | 0.84 | ADORA2A (0.66) | ADORA3ADORA2AADORA2BADORA1HSD17B10 | |
| SCHEMBL22573343 | 0.83 | TSHR (0.58) | ADORA3ADORA2AADORA2BADORA1TSHR | |
| SCHEMBL22573501 | 0.83 | ADORA3 (0.60) | ADORA3ADORA2AADORA2BADORA1HSD17B10 | |
| SCHEMBL22573702 | 0.83 | ADORA2A (0.68) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL22573552 | 0.82 | ADORA2A (0.66) | ADORA3ADORA2AADORA2BADORA1HSD17B10 | |
| SCHEMBL22573408 | 0.82 | ADORA3 (0.60) | ADORA3ADORA2AADORA2BADORA1HSD17B10 | |
| SCHEMBL22573570 | 0.81 | GRM5 (0.61) | HSD17B10ALDH1A1HPGDSMN1; SMN2GRM5 | |
| SCHEMBL22573464 | 0.81 | ADORA2A (0.57) | ADORA3ADORA2AADORA2BADORA1HSD17B10 | |
| SCHEMBL22573768 | 0.81 | ADORA2A (0.65) | ADORA3ADORA2AADORA2BADORA1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728236-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE USE FOR THE TREATMENT OF CANCER | Adorx therapeutics Limited (GB) | 2020-10-28 | — | — | EP | claimed |