Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.64 |
| ▸ | BAD | Q92934 | 1/20 | 0.64 |
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.42 |
| ▸ | HNF4A | P41235 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257653 | 1.00 | BCL2L1 (0.64) | BCL2L1BADACMSDHNF4AXDH | |
| SCHEMBL2255098 | 0.82 | BCL2L1 (0.67) | BCL2L1BADACMSDHNF4ALCK | |
| SCHEMBL2251560 | 0.82 | BCL2L1 (0.67) | BCL2L1BADACMSDHNF4ALCK | |
| SCHEMBL2251565 | 0.82 | BCL2L1 (0.67) | BCL2L1BADACMSDHNF4ALCK | |
| SCHEMBL2255104 | 0.82 | BCL2L1 (0.67) | BCL2L1BADACMSDHNF4ALCK | |
| SCHEMBL2257798 | 0.82 | BCL2L1 (0.60) | BCL2L1BADDHODHRELAKDM4E | |
| SCHEMBL2257799 | 0.82 | BCL2L1 (0.60) | BCL2L1BADDHODHRELAKDM4E | |
| SCHEMBL2254358 | 0.78 | BCL2L1 (0.77) | BCL2L1BADHNF4A | |
| SCHEMBL2254360 | 0.78 | BCL2L1 (0.77) | BCL2L1BADHNF4A | |
| SCHEMBL2252620 | 0.78 | BCL2L1 (0.72) | BCL2L1BADACMSDHNF4ADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904047-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7989656-B2 | Biaryl carboxylic acid apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100234456-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| US-7750004-B2 | Apoptosis promoters | ABBOTT LABORATORIES (US) | 2010-07-06 | — | — | US | disclosed |
| US-20070135392-A1 | Apoptosis promoters | ABBVIE INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234456-A1 | APOPTOSIS PROMOTERS | MCL1, BAX, BCL2 | BCL2L1 5/4885BAD 11/4885ACMSD 4767/4885 |
| US-20070135392-A1 | Apoptosis promoters | MCL1, BAX, BCL2 | BCL2L1 5/4885BAD 11/4885ACMSD 4767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.