Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.60 |
| ▸ | BAD | Q92934 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 4/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257799 | 1.00 | BCL2L1 (0.60) | BCL2L1BADPTPN1ESR1ESR2 | |
| SCHEMBL2252475 | 0.85 | BCL2L1 (0.51) | BCL2L1BADPTPN1ESR1ESR2 | |
| SCHEMBL2252467 | 0.85 | BCL2L1 (0.51) | BCL2L1BADPTPN1ESR1ESR2 | |
| SCHEMBL2253025 | 0.84 | BCL2L1 (0.56) | BCL2L1BADDHODHRELAMEN1 | |
| SCHEMBL2253023 | 0.84 | BCL2L1 (0.56) | BCL2L1BADDHODHRELAMEN1 | |
| SCHEMBL2254705 | 0.83 | BCL2L1 (0.49) | BCL2L1BADPTPN1ESR1ESR2 | |
| SCHEMBL2254708 | 0.83 | BCL2L1 (0.49) | BCL2L1BADPTPN1ESR1ESR2 | |
| SCHEMBL2257653 | 0.82 | BCL2L1 (0.64) | BCL2L1BADDHODHRELAMEN1 | |
| SCHEMBL2257657 | 0.82 | BCL2L1 (0.64) | BCL2L1BADDHODHRELAMEN1 | |
| SCHEMBL2255098 | 0.82 | BCL2L1 (0.67) | BCL2L1BADPTPN1DHODHRELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904047-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7989656-B2 | Biaryl carboxylic acid apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100234456-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| US-7750004-B2 | Apoptosis promoters | ABBOTT LABORATORIES (US) | 2010-07-06 | — | — | US | disclosed |
| EP-1904047-A2 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2008-04-02 | — | — | EP | disclosed |
| US-20070135392-A1 | Apoptosis promoters | ABBVIE INC. | 2007-06-14 | — | — | US | disclosed |
| WO-2007008627-A2 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234456-A1 | APOPTOSIS PROMOTERS | MCL1, BAX, BCL2 | BCL2L1 5/4885BAD 11/4885PTPN1 3895/4885 |
| US-20070135392-A1 | Apoptosis promoters | MCL1, BAX, BCL2 | BCL2L1 5/4885BAD 11/4885PTPN1 3895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.