SCHEMBL22579550

SCHEMBL22579550

CCC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O[C@@H]1C[C@@H]2c3cc(OC)c(OC)cc3CCN2C[C@H]1CC(C)C

nearest known ligand 0.67

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.65
TBXA2R P21731 1/20 0.65
PTGS1 P23219 1/20 0.65
OPRM1 P35372 1/20 0.65
KCNH2 Q12809 1/20 0.65
SLC18A2 Q05940 10/20 0.57
HTR2A P28223 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22612151 0.93 HTR1A (0.70) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL22612169 0.93 HTR1A (0.70) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL22612168 0.93 HTR1A (0.70) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL19024413 0.93 HTR1A (0.70) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL20049853 0.93 HTR1A (0.70) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL19024412 0.93 HTR1A (0.70) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL19024411 0.93 HTR1A (0.70) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL24520555 0.88 HTR1A (0.63) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL871905 0.84 HTR1A (0.72) HTR1ATBXA2RPTGS1OPRM1KCNH2
SCHEMBL29929867 0.83 HTR1A (0.79) HTR1ATBXA2RPTGS1OPRM1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020213014-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF VALBENAZINE AND ITS SALTS MYLAN LABORATORIES LIMITED (IN) 2020-10-22 WO disclosed